Scientists capture stunning real-time images of DNA damage and repair

Scientists have created a live-cell DNA sensor that reveals how damage appears and disappears inside living cells, capturing the entire repair sequence as it unfolds. Instead of freezing cells at different points, researchers can now watch damage flare up, track repair proteins rushing to the site, and see the moment the DNA is restored. Built from a natural protein that binds gently and briefly to damaged DNA, the sensor offers a true-to-life view of the cell’s internal emergency response.

Cell Biology

7-Year Study Reveals Rheumatoid Arthritis Begins Long Before Symptoms

The seven-year study identifies early warning signs that may allow doctors to detect the disease before it develops, potentially sparing patients years of pain and disability. Scientists have found that rheumatoid arthritis (RA) does not begin when pain becomes noticeable. Instead, it starts quietly many years earlier. RA is a serious autoimmune disorder that leads [...]

Biology

70-Year Mystery Solved: Scientists Finally Discover How Lifesaving Pregnancy Drug Really Works

A Penn-led research team has uncovered how hydralazine, one of the oldest blood pressure medications and a standard treatment for preeclampsia, functions at the molecular level. In the process, they made an unexpected finding: it can also stop the growth of aggressive brain tumors. Over the last 70 years, hydralazine has been a critical medication [...]

Biology